Structural highlights
Function
FFT3_SCHPO DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization. Required for maintaining a heterochromatin chromatin structure at centromeres and subtelomeres by protecting these regions from euchromatin assembly. Enhances the nucleotide exchange activity of the pim1 guanine nucleotide exchange factor and abolishes histone-H3-mediated RanGAP inhibition. Involved in the construction of the centromeres.[1] [2] [3]
References
- ↑ Kusano A, Yoshioka T, Nishijima H, Nishitani H, Nishimoto T. Schizosaccharomyces pombe RanGAP homolog, SpRna1, is required for centromeric silencing and chromosome segregation. Mol Biol Cell. 2004 Nov;15(11):4960-70. PMID:15317843 doi:10.1091/mbc.e04-01-0067
- ↑ Ohba T, Nishijima H, Nishitani H, Nishimoto T. Schizosaccharomyces pombe Snf2SR, a novel SNF2 family protein, interacts with Ran GTPase and modulates both RanGEF and RanGAP activities. Genes Cells. 2008 Jun;13(6):571-82. PMID:18422602 doi:10.1111/j.1365-2443.2008.01190.x
- ↑ Strålfors A, Walfridsson J, Bhuiyan H, Ekwall K. The FUN30 chromatin remodeler, Fft3, protects centromeric and subtelomeric domains from euchromatin formation. PLoS Genet. 2011 Mar;7(3):e1001334. PMID:21437270 doi:10.1371/journal.pgen.1001334
