7ycx

The structure of INTAC-PEC complex

spinqualitylabelsall models 7ycx, resolution 4.18Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7ycx is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.18Å Ligands: MG, MN, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease INT1_HUMAN The disease is caused by variants affecting the gene represented in this entry. Function INT1_HUMAN Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).

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