7yhr

Anti-CRISPR protein AcrIC5

spinqualitylabelsall models 7yhr, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7yhr is a 1 chain structure with sequence from Pseudomonas delhiensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.45Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A239N0M2_9PSED Publication Abstract from PubMed As a result of the long-term battle of bacteria and archaea against invaders such as viruses and genetic mobile elements, they have developed CRISPR-Cas systems for self-defense, which allows them to remove the viral genetic material introduced into host cells via infection. To fight against this bacterial immune system, however, viruses have also evolved to produce multiple anti-CRISPR proteins that can inhibit the bacterial CRISPR-Cas system. In this study, we introduced a tentative inhibitory activity against a type I-C CRISPR-Cas system by determining the crystal structure of AcrIC5 from Pseudomonas delhiensis. Structural analysis revealed that AcrIC5 was composed of noble folds comprising two antiparallel sheets and three helices. Although AcrIC5 did not directly interact with either the type I-C cascade from Neisseria lactamia or the type I-F cascade from Pseudomonas aeruginosa in our analysis, a highly acidic surface feature indicated that AcrIC5 may be DNA mimic Acrs that directly binds to the target DNA binding site in type I-C cascade and inhibits the recruitment of the target DNA to this cascade. High-resolution crystal structure of the anti-CRISPR protein AcrIC5.,Kang YJ, Park HH Biochem Biophys Res Commun. 2022 Oct 15;625:102-108. doi: , 10.1016/j.bbrc.2022.08.005. Epub 2022 Aug 5. PMID:35952606 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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