Structural highlights
Function
MLRC_SPHSX Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) (PubMed:11769251, PubMed:8899999). Cleaves both linear MC and the tetrapeptide degradation product of MC (PubMed:11769251). Cleaves the Adda-Glu peptide bond of linear MC heptapeptides (PubMed:22591122).[1] [2] [3]
References
- ↑ Bourne DG, Riddles P, Jones GJ, Smith W, Blakeley RL. Characterisation of a gene cluster involved in bacterial degradation of the cyanobacterial toxin microcystin LR. Environ Toxicol. 2001;16(6):523-34 PMID:11769251
- ↑ Dziga D, Wasylewski M, Szetela A, Bocheńska O, Wladyka B. Verification of the role of MlrC in microcystin biodegradation by studies using a heterologously expressed enzyme. Chem Res Toxicol. 2012 Jun 18;25(6):1192-4. PMID:22591122 doi:10.1021/tx300174e
- ↑ Bourne DG, Jones GJ, Blakeley RL, Jones A, Negri AP, Riddles P. Enzymatic pathway for the bacterial degradation of the cyanobacterial cyclic peptide toxin microcystin LR. Appl Environ Microbiol. 1996 Nov;62(11):4086-94. PMID:8899999 doi:10.1128/aem.62.11.4086-4094.1996
