7yrw

Solution structures of a disulfide-directed multicyclic peptide with affinity for HER2

spinqualitylabelsall models 7yrw Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7yrw is a 1 chain structure with sequence from Synthetic construct. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 15 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide formats for drug design and discovery as they have the potential to combine the best characteristics of small molecules and proteins. However, the development of multicyclic peptides is largely limited to naturally occurring products. It remains a big challenge to develop multicyclic peptides with new structures and functions without recourse to the existing natural scaffolds. Here, we report a general and robust method relying on the utility of new disulfide-directing motifs for designing and discovering diverse multicyclic peptides with potent protein-binding capability. These peptides, referred to as disulfide-directed multicyclic peptides (DDMPs), are tolerant to extensive sequence manipulations and variations of disulfide-pairing frameworks, enabling the development of de novo DDMP libraries useful for ligand and drug discovery. This study opens a new avenue for creating a new generation of multicyclic peptides in sequence and structure space inaccessible by natural scaffolds, thus would greatly benefit the field of peptide drug discovery. Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs.,Lu S, Fan S, Xiao S, Li J, Zhang S, Wu Y, Kong C, Zhuang J, Liu H, Zhao Y, Wu C J Am Chem Soc. 2023 Jan 25;145(3):1964-1972. doi: 10.1021/jacs.2c12462. Epub 2023 , Jan 12. PMID:36633218 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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