7z05

White Bream virus N7-Methyltransferase

spinqualitylabelsall models 7z05, resolution 2.33Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7z05 is a 1 chain structure with sequence from White bream virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.33Å Ligands: NA, PEG, SAH Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function R1AB_WBV24 Catalyzes the RNA N7-guanylyltransferase reaction to methylate the core cap structure GpppN-RNA into the type-0 cap (m)GpppN-RNA. The 3C-like serine proteinase is responsible for the majority of cleavages. The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. The exoribonuclease acts on ssRNA in a 3' to 5' direction (PubMed:30058998). Most active on dsRNA substrates containing one or two non-paired 3'-terminal nucleotides, thereby probably increasing the fidelity of the viral RNA-dependent RNA polymerase by excising RNA 3'-end mismatches during viral RNA replication (PubMed:30058998). NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. Catalyzes the RNA 2'-O-ribose methyltransferase reaction to methylate the type-0 cap into the type-1 cap (m)GpppN(m)-RNA.[UniProtKB:P0C6X7]

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