| Structural highlights
Function
TACA1_SALT1 Antitoxin component of a type II toxin-antitoxin (TA) system (PubMed:27264868, PubMed:34556858). Counteracts the toxic effect of cognate toxin TacT1 (T8), but not TacT2 or TacT3 (PubMed:27264868, PubMed:34556858). Plays a role in persister cell formation (PubMed:24408438).[1] [2] [3] The TacA1-TacT1 complex binds (and probably represses) its own promoter DNA but not that of tacA3-tacT3, it does not repress the tacA3-tacT3 promoter.[4]
References
- ↑ Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW. Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science. 2014 Jan 10;343(6167):204-8. PMID:24408438 doi:10.1126/science.1244705
- ↑ Cheverton AM, Gollan B, Przydacz M, Wong CT, Mylona A, Hare SA, Helaine S. A Salmonella Toxin Promotes Persister Formation through Acetylation of tRNA. Mol Cell. 2016 May 31. pii: S1097-2765(16)30139-3. doi:, 10.1016/j.molcel.2016.05.002. PMID:27264868 doi:https://dx.doi.org/10.1016/j.molcel.2016.05.002
- ↑ Grabe GJ, Giorgio RT, Hall AMJ, Morgan RML, Dubois L, Sisley TA, Rycroft JA, Hare SA, Helaine S. Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nat Chem Biol. 2021 Dec;17(12):1296-1304. PMID:34556858 doi:10.1038/s41589-021-00862-y
- ↑ Grabe GJ, Giorgio RT, Wieczór M, Gollan B, Sargen M, Orozco M, Hare SA, Helaine S. Molecular stripping underpins derepression of a toxin-antitoxin system. Nat Struct Mol Biol. 2024 Jul;31(7):1050-1060. PMID:38538913 doi:10.1038/s41594-024-01253-2
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