7zj3

Structure of TRIM2 RING domain in complex with UBE2D1~Ub conjugate

spinqualitylabelsall models 7zj3, resolution 2.53Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7zj3 is a 12 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.53Å Ligands: ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease TRIM2_HUMAN Charcot-Marie-Tooth disease type 2R. The disease is caused by variants affecting the gene represented in this entry. Function TRIM2_HUMAN UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.[UniProtKB:Q9ESN6]

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