7zma

Ketosynthase domain of module 4 from Brevibacillus Brevis orphan BGC11

spinqualitylabelsall models 7zma, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7zma is a 2 chain structure with sequence from Brevibacillus brevis NBRC 100599. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.9Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C0ZGQ6_BREBN Publication Abstract from PubMed Polyketide synthases (PKSs) are predominantly microbial biosynthetic enzymes. They assemble highly potent bioactive natural products from simple carboxylic acid precursors. The most versatile families of PKSs are organized as assembly lines of functional modules. Each module performs one round of precursor extension and optional modification, followed by directed transfer of the intermediate to the next module. While enzymatic domains and even modules of PKSs are well understood, the higher-order modular architecture of PKS assembly lines remains elusive. Here, we visualize a PKS bimodule core using cryo-electron microscopy and resolve a two-dimensional meshwork of the bimodule core formed by homotypic interactions between modules. The sheet-like organization provides the framework for efficient substrate transfer and for sequestration of trans-acting enzymes required for polyketide production. The structure of a polyketide synthase bimodule core.,Tittes YU, Herbst DA, Martin SFX, Munoz-Hernandez H, Jakob RP, Maier T Sci Adv. 2022 Sep 23;8(38):eabo6918. doi: 10.1126/sciadv.abo6918. Epub 2022 Sep , 21. PMID:36129979 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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