7zzq

BcsH-BcsD 'beads-on-a-string' filament, local refine

spinqualitylabelsall models 7zzq, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7zzq is a 30 chain structure with sequence from Komagataeibacter hansenii ATCC 23769. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.6Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q76KJ6_NOVHA Publication Abstract from PubMed Cellulose, the most abundant biopolymer on Earth, is not only the predominant constituent of plants but also a key extracellular polysaccharide in the biofilms of many bacterial species. Depending on the producers, chemical modifications, and three-dimensional assemblies, bacterial cellulose (BC) can present diverse degrees of crystallinity. Highly ordered, or crystalline, cellulose presents great economical relevance due to its ever-growing number of biotechnological applications. Even if some acetic acid bacteria have long been identified as BC superproducers, the molecular mechanisms determining the secretion of crystalline versus amorphous cellulose remain largely unknown. Here, we present structural and mechanistic insights into the role of the accessory subunits BcsH (CcpAx) and BcsD (CesD) that determine crystalline BC secretion in the Gluconacetobacter lineage. We show that oligomeric BcsH drives the assembly of BcsD into a supramolecular cytoskeletal scaffold that likely stabilizes the cellulose-extruding synthase nanoarrays through an unexpected inside-out mechanism for secretion system assembly. Bacterial crystalline cellulose secretion via a supramolecular BcsHD scaffold.,Abidi W, Decossas M, Torres-Sanchez L, Puygrenier L, Letoffe S, Ghigo JM, Krasteva PV Sci Adv. 2022 Dec 16;8(50):eadd1170. doi: 10.1126/sciadv.add1170. Epub 2022 Dec , 16. PMID:36525496 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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