| Structural highlights
8a8q is a 4 chain structure with sequence from Drosophila melanogaster and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | X-ray diffraction, Resolution 1.465Å |
| Ligands: | ACE, ACT, MYK, NH2, NLE |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
SCAL_DROME Transcription factor which plays a key role in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Sd promotes nuclear localization of Yki. Involved in the regulation of cell-specific gene expression during development, particularly in the differentiation of the nervous system. When in combination with vestigial (vg) it acts as a transcriptional activation complex that regulates gene expression in the wing. Binding to vg switches the DNA target selectivity of sd. Required autonomously for cell proliferation and viability within the wing blade. Required for proper sensory organ precursor (SOP) differentiation at the wing margin; required for correct expression of sens.[1] [2] [3] [4] [5] [6]
References
- ↑ Liu X, Grammont M, Irvine KD. Roles for scalloped and vestigial in regulating cell affinity and interactions between the wing blade and the wing hinge. Dev Biol. 2000 Dec 15;228(2):287-303. PMID:11112330 doi:https://dx.doi.org/10.1006/dbio.2000.9939
- ↑ Srivastava A, Bell JB. Further developmental roles of the Vestigial/Scalloped transcription complex during wing development in Drosophila melanogaster. Mech Dev. 2003 May;120(5):587-96. PMID:12782275
- ↑ Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell. 2008 Mar;14(3):377-87. doi: 10.1016/j.devcel.2008.01.006. Epub 2008 Feb , 7. PMID:18258485 doi:https://dx.doi.org/10.1016/j.devcel.2008.01.006
- ↑ Goulev Y, Fauny JD, Gonzalez-Marti B, Flagiello D, Silber J, Zider A. SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila. Curr Biol. 2008 Mar 25;18(6):435-41. doi: 10.1016/j.cub.2008.02.034. Epub 2008 , Feb 28. PMID:18313299 doi:https://dx.doi.org/10.1016/j.cub.2008.02.034
- ↑ Simmonds AJ, Liu X, Soanes KH, Krause HM, Irvine KD, Bell JB. Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila. Genes Dev. 1998 Dec 15;12(24):3815-20. PMID:9869635
- ↑ Halder G, Polaczyk P, Kraus ME, Hudson A, Kim J, Laughon A, Carroll S. The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. Genes Dev. 1998 Dec 15;12(24):3900-9. PMID:9869643
|
