Structural highlights
Function
HPS_STRCL Terpene synthase that catalyzes the conversion of geranylgeranyl diphosphate (GGPP) into a mixture of diterpenes, including hydropyrene (HP), hydropyrenol (HPol), isoelisabethatriene and traces of isoelisabethatriene B (PubMed:25605043, PubMed:28696553, PubMed:35965858). Hydropyrene is the main product (PubMed:25605043, PubMed:28696553). Some other diterpenoids are also produced in very low quantities (PubMed:25605043).[1] [2] [3]
References
- ↑ Yamada Y, Arima S, Nagamitsu T, Johmoto K, Uekusa H, Eguchi T, Shin-ya K, Cane DE, Ikeda H. Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host. J Antibiot (Tokyo). 2015 Jun;68(6):385-94. PMID:25605043 doi:10.1038/ja.2014.171
- ↑ Rinkel J, Rabe P, Chen X, Köllner TG, Chen F, Dickschat JS. Mechanisms of the Diterpene Cyclases β-Pinacene Synthase from Dictyostelium discoideum and Hydropyrene Synthase from Streptomyces clavuligerus. Chemistry. 2017 Aug 4;23(44):10501-10505. PMID:28696553 doi:10.1002/chem.201702704
- ↑ Zev S, Ringel M, Driller R, Loll B, Brück T, Major DT. Understanding the competing pathways leading to hydropyrene and isoelisabethatriene. Beilstein J Org Chem. 2022 Aug 4;18:972-978. PMID:35965858 doi:10.3762/bjoc.18.97
