8dye

Crystal structure of human SDHA-SDHAF4 assembly intermediate

spinqualitylabelsall models 8dye, resolution 1.44Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8dye is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.44Å Ligands: EDO, FAD, GOL, MLI, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease SDHA_HUMAN Familial isolated dilated cardiomyopathy;Hereditary pheochromocytoma-paraganglioma;Gastrointestinal stromal tumor;Isolated succinate-CoQ reductase deficiency. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Function SDHA_HUMAN Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act as a tumor suppressor (PubMed:20484225).

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