8etk

Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe

spinqualitylabelsall models 8etk, resolution 1.83Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8etk is a 2 chain structure with sequence from Lactobacillus gasseri. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.83Å Ligands: NA, WU9 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CBH_LACGA Bile salt hydrolase that catalyzes the deconjugation of glycine- and taurine-linked bile salts, which occurs naturally in the intestines of humans, releasing amino acid residues and deconjugated bile salts (bile acids) (PubMed:34066735). Can hydrolyze the amide bond in the bile salts taurocholate (TCA), taurodeoxycholate (TDCA), taurochenodeoxycholate (TCDCA), glycocholate (GCA) and glycodeoxycholate (GDCA) (PubMed:34066735). Shows highest activity toward the taurine-conjugated bile salts TCA and TCDCA (PubMed:34066735). The activity toward the other three substrates (TDCA, GCA and GDCA) is relatively low (PubMed:34066735). This enzyme likely contributes to bile salt resistance of the strain and may be associated with survival capability of strain JCM1131 within the human intestine by bile detoxification (PubMed:34066735).

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