8fr5

Crystal structure of the Human Smacovirus 1 Rep domain

spinqualitylabelsall models 8fr5, resolution 1.33Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8fr5 is a 1 chain structure with sequence from Human smacovirus 1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.33Å Ligands: MN, NA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0B5CMT4_9VIRU Publication Abstract from PubMed Replication initiator proteins (Reps) from the HUH endonuclease family process specific single-stranded DNA sequences to initiate rolling-circle replication in viruses. Here, the first crystal structure of the apo state of a Rep domain from the smacovirus family is reported. The structure of the human smacovirus 1 Rep domain was obtained at 1.33 A resolution and represents an expansion of the HUH endonuclease superfamily, allowing greater diversity in bioconjugation-tag applications. The crystal structure of the human smacovirus 1 Rep domain.,Limon LK, Shi K, Dao A, Rugloski J, Tompkins KJ, Aihara H, Gordon WR, Evans RL 3rd Acta Crystallogr F Struct Biol Commun. 2023 Dec 1;79(Pt 12):295-300. doi: , 10.1107/S2053230X23009536. Epub 2023 Dec 5. PMID:38051309 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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