8fy4

Structure of NOT1:NOT10:NOT11 module of the chicken CCR4-NOT complex

spinqualitylabelsall models 8fy4, resolution 2.57Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8fy4 is a 3 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.57Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A8V0ZE30_CHICK Publication Abstract from PubMed NOT1, NOT10, and NOT11 form a conserved module in the CCR4-NOT complex, critical for post-transcriptional regulation in eukaryotes, but how this module contributes to the functions of the CCR4-NOT remains poorly understood. Here, we present cryo-EM structures of human and chicken NOT1:NOT10:NOT11 ternary complexes to sub-3 A resolution, revealing an evolutionarily conserved, flexible structure. Through biochemical dissection studies, which include the Drosophila orthologs, we show that the module assembly is hierarchical, with NOT11 binding to NOT10, which then organizes it for binding to NOT1. A short proline-rich motif in NOT11 stabilizes the entire module assembly. Structure and assembly of the NOT10:11 module of the CCR4-NOT complex.,Levdansky Y, Raisch T, Deme JC, Pekovic F, Elmlund H, Lea SM, Valkov E Commun Biol. 2023 Jul 17;6(1):739. doi: 10.1038/s42003-023-05122-4. PMID:37460791 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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