8gu3

Crystal structure of Caenorhabditis elegans METT-10 methyltransferase domain

spinqualitylabelsall models 8gu3, resolution 3.01Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8gu3 is a 1 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.01Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MET16_CAEEL RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating splicing of S-adenosylmethionine synthase transcripts (sams-3, sams-4 and sams-5) (PubMed:33930289). Able to N6-methylate a subset of mRNAs containing the 5'UACAGAAAC-3' nonamer sequence (PubMed:33930289). Plays a key role in S-adenosyl-L-methionine homeostasis: under rich-diet conditions, catalyzes N6-methylation of S-adenosylmethionine synthase mRNAs (sams-3, sams-4 and sams-5), directly inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:33930289). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA) (PubMed:33930289). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development (PubMed:19596901, PubMed:19752194). Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate (PubMed:19596901, PubMed:19752194). Plays a role in the development of the vulva, somatic gonad and embryo (PubMed:19596901).

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