| Structural highlights
8h68 is a 1 chain structure with sequence from Caenorhabditis elegans and Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | X-ray diffraction, Resolution 2.2Å |
| Ligands: | EPE, GLC, GLY, MG, OGA, PEG, PRD_900010, TRS |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
MALE_ECO57 Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).NMAD1_CAEEL Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:25936839). N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance (PubMed:25936839). Plays an essential role in DNA replication and repair in the germline during meiosis (PubMed:31283754). Binds to components of the DNA replication machinery such as top-2, and directs their localization to DNA to control DNA replication (PubMed:31283754).[1] [2]
References
- ↑ Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizábal-Corrales D, Hsu CH, Aravind L, He C, Shi Y. DNA Methylation on N6-Adenine in C. elegans. Cell. 2015 May 7;161(4):868-78. PMID:25936839 doi:10.1016/j.cell.2015.04.005
- ↑ Wang SY, Mao H, Shibuya H, Uzawa S, O'Brown ZK, Wesenberg S, Shin N, Saito TT, Gao J, Meyer BJ, Colaiácovo MP, Greer EL. The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline. PLoS Genet. 2019 Jul 8;15(7):e1008252. PMID:31283754 doi:10.1371/journal.pgen.1008252
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