8hp8

Crystal Structure of Engineered Endolysin EC340 derived from Gram-Negative Bacteria targeted Bacteriophage

spinqualitylabelsall models 8hp8, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8hp8 is a 3 chain structure with sequence from Escherichia phage PBEC131. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.397Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Endolysins produced by bacteriophages play essential roles in the release of phage progeny by degrading the peptidoglycan layers of the bacterial cell wall. Bacteriophage-encoded endolysins have emerged as a new class of antibacterial agents to combat surging antibiotic resistance. The crystal structure of mtEC340M, an engineered endolysin EC340 from the PBEC131 phage that infects Escherichia coli, was determined. The crystal structure of mtEC340M at 2.4 A resolution consists of eight alpha-helices and two loops. The three active residues of mtEC340M were predicted by structural comparison with peptidoglycan-degrading lysozyme. Crystal structure of the engineered endolysin mtEC340M.,Wang JM, Seok SH, Yoon WS, Kim JH, Seo MD Acta Crystallogr F Struct Biol Commun. 2023 May 1;79(Pt 5):105-110. doi: , 10.1107/S2053230X23002583. Epub 2023 May 3. PMID:37132476 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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