8i0h

Closed conformation of CTPS with dATP dUTP dGTP and DON

spinqualitylabelsall models 8i0h, resolution 3.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8i0h is a 4 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.4Å Ligands: DGT, DTP, DUT, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PYRG_DROME Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). Isoform 1 is required for cytoophidium assembly in female germline cells.

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