8i2z

Cryo-EM structure of the zeaxanthin-bound kin4B8

spinqualitylabelsall models 8i2z, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8i2z is a 1 chain structure with sequence from Uncultured Bdellovibrionales bacterium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.3Å Ligands: K3I, RET Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A977XLG0_9BACT Publication Abstract from PubMed Energy transfer from light-harvesting ketocarotenoids to the light-driven proton pump xanthorhodopsins has been previously demonstrated in two unique cases: an extreme halophilic bacterium(1) and a terrestrial cyanobacterium(2). Attempts to find carotenoids that bind and transfer energy to abundant rhodopsin proton pumps(3) from marine photoheterotrophs have thus far failed(4-6). Here we detected light energy transfer from the widespread hydroxylated carotenoids zeaxanthin and lutein to the retinal moiety of xanthorhodopsins and proteorhodopsins using functional metagenomics combined with chromophore extraction from the environment. The light-harvesting carotenoids transfer up to 42% of the harvested energy in the violet- or blue-light range to the green-light absorbing retinal chromophore. Our data suggest that these antennas may have a substantial effect on rhodopsin phototrophy in the world's lakes, seas and oceans. However, the functional implications of our findings are yet to be discovered. Phototrophy by antenna-containing rhodopsin pumps in aquatic environments.,Chazan A, Das I, Fujiwara T, Murakoshi S, Rozenberg A, Molina-Marquez A, Sano FK, Tanaka T, Gomez-Villegas P, Larom S, Pushkarev A, Malakar P, Hasegawa M, Tsukamoto Y, Ishizuka T, Konno M, Nagata T, Mizuno Y, Katayama K, Abe-Yoshizumi R, Ruhman S, Inoue K, Kandori H, Leon R, Shihoya W, Yoshizawa S, Sheves M, Nureki O, Beja O Nature. 2023 Mar;615(7952):535-540. doi: 10.1038/s41586-023-05774-6. Epub 2023 , Mar 1. PMID:36859551 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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