8i4n

Crystal strcuture of 6-phosphogluconate dehydrogenase from Corynebacterium glutamicum

spinqualitylabelsall models 8i4n, resolution 2.41Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8i4n is a 2 chain structure with sequence from Corynebacterium glutamicum ATCC 13032. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.41Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q8NQI2_CORGL Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.[PIRNR:PIRNR000109] Publication Abstract from PubMed Corynebacterium glutamicum (C. glutamicum) has been considered a very important and meaningful industrial microorganism for the production of amino acids worldwide. To produce amino acids, cells require nicotinamide adenine dinucleotide phosphate (NADPH), which is a biological reducing agent. The pentose phosphate pathway (PPP) can supply NADPH in cells via the 6-phosphogluconate dehydrogenase (6PGD) enzyme, which is an oxidoreductase that converts 6-phosphogluconate (6PG) to ribulose 5-phosphate (Ru5P), to produce NADPH. In this study, we identified the crystal structure of 6PGD_apo and 6PGD_NADP from C. glutamicum ATCC 13032 (Cg6PGD) and reported our biological research based on this structure. We identified the substrate binding site and co-factor binding site of Cg6PGD, which are crucial for understanding this enzyme. Based on the findings of our research, Cg6PGD is expected to be used as a NADPH resource in the food industry and as a drug target in the pharmaceutical industry. Crystal Structures of 6-Phosphogluconate Dehydrogenase from Corynebacterium glutamicum.,Yu H, Hong J, Seok J, Seu YB, Kim IK, Kim KJ J Microbiol Biotechnol. 2023 Oct 28;33(10):1361-1369. doi: , 10.4014/jmb.2305.05002. Epub 2023 Jun 27. PMID:37417004 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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