Structural highlights
Function
RMC1_DROME Positive regulator of the Rab7 guanyl-nucleotide exchange activity of the Mon1-Ccz1 complex, possibly by enhancing its endosomal membrane association (PubMed:32391792, PubMed:32499409). As part of the Mon1-Ccz1 complex involved in endolysosomal biogenesis possibly by mediating Rab conversion, the replacement of Rab5 with Rab7 during late endosome maturation (PubMed:32499409).[1] [2]
References
- ↑ Langemeyer L, Borchers AC, Herrmann E, Füllbrunn N, Han Y, Perz A, Auffarth K, Kümmel D, Ungermann C. A conserved and regulated mechanism drives endosomal Rab transition. Elife. 2020 May 11;9:e56090. PMID:32391792 doi:10.7554/eLife.56090
- ↑ Dehnen L, Janz M, Verma JK, Psathaki OE, Langemeyer L, Fröhlich F, Heinisch JJ, Meyer H, Ungermann C, Paululat A. A trimeric metazoan Rab7 GEF complex is crucial for endocytosis and scavenger function. J Cell Sci. 2020 Jul 9;133(13):jcs247080. PMID:32499409 doi:10.1242/jcs.247080
