Structural highlights
8k1p is a 3 chain structure with sequence from Mycobacterium tuberculosis H37Rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | Electron Microscopy, Resolution 3.4Å |
| Ligands: | ADP, ATP, CDL, MG, VO4 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
MEPRM_MYCTU Probably part of the ABC transporter complex Rv1217c-Rv1218c involved in the resistance to a wide range of structurally unrelated drugs (PubMed:23143285). Probably responsible for the translocation of the substrate across the membrane (Probable).[1]
References
- ↑ Wang K, Pei H, Huang B, Zhu X, Zhang J, Zhou B, Zhu L, Zhang Y, Zhou FF. The expression of ABC efflux pump, Rv1217c-Rv1218c, and its association with multidrug resistance of Mycobacterium tuberculosis in China. Curr Microbiol. 2013 Mar;66(3):222-6. PMID:23143285 doi:10.1007/s00284-012-0215-3
