8ou1

Crystal structure of the SPOC domain of mouse SPOCD1

spinqualitylabelsall models 8ou1, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ou1 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.7Å Ligands: FLC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SPOC1_MOUSE Essential excecutor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:32674113). Associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (PubMed:32674113). Tethering of PIWIL4 to a nascent transposable element transcript recruits repressive chromatin remodeling activities and the de novo methylation apparatus through SPOCD1 (PubMed:32674113). Not required for piRNA biosynthesis (PubMed:32674113).

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