| Structural highlights
Function
TCPR1_HUMAN Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation.[1] [2]
References
- ↑ Ogawa M, Yoshikawa Y, Kobayashi T, Mimuro H, Fukumatsu M, Kiga K, Piao Z, Ashida H, Yoshida M, Kakuta S, Koyama T, Goto Y, Nagatake T, Nagai S, Kiyono H, Kawalec M, Reichhart JM, Sasakawa C. A Tecpr1-dependent selective autophagy pathway targets bacterial pathogens. Cell Host Microbe. 2011 May 19;9(5):376-89. doi: 10.1016/j.chom.2011.04.010. PMID:21575909 doi:https://dx.doi.org/10.1016/j.chom.2011.04.010
- ↑ Chen D, Fan W, Lu Y, Ding X, Chen S, Zhong Q. A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol Cell. 2012 Mar 9;45(5):629-41. doi: 10.1016/j.molcel.2011.12.036. Epub 2012, Feb 16. PMID:22342342 doi:https://dx.doi.org/10.1016/j.molcel.2011.12.036
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