8ppl

MERS-CoV Nsp1 bound to the human 43S pre-initiation complex

spinqualitylabelsall models 8ppl, resolution 2.65Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ppl is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.65Å Ligands: 1MA, 1MG, 2MG, 4AC, 5MC, 6MZ, A2M, AME, B8N, G7M, GTP, H2U, HY3, IAS, MA6, MET, MG, NMM, OMC, OMG, OMU, PSU, SAC, T6A, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function EIF3K_HUMAN Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.

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