8pty

Cryo-EM structure of human Elp123 in complex with 5'-deoxyadenosine and methionine

spinqualitylabelsall models 8pty, resolution 3.58Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8pty is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.58Å Ligands: 5AD, MET Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease ELP1_HUMAN Familial dysautonomia. The disease is caused by mutations affecting the gene represented in this entry. Function ELP1_HUMAN May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis (By similarity). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity).[UniProtKB:Q7TT37]

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