8q28

Se-Met labelled TtX122A - A domain of unknown function from the Teredinibacter turnerae protein TERTU_3803

spinqualitylabelsall models 8q28, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8q28 is a 2 chain structure with sequence from Teredinibacter turnerae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.8Å Ligands: CA, EDO, MG, MSE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C5BSV8_TERTT Publication Abstract from PubMed The discovery of lytic polysaccharide monooxygenases (LPMOs), a family of copper-dependent enzymes that play a major role in polysaccharide degradation, has revealed the importance of oxidoreductases in the biological utilization of biomass. In fungi, a range of redox proteins have been implicated as working in harness with LPMOs to bring about polysaccharide oxidation. In bacteria, less is known about the interplay between redox proteins and LPMOs, or how the interaction between the two contributes to polysaccharide degradation. We therefore set out to characterize two previously unstudied proteins from the shipworm symbiont Teredinibacter turnerae that were initially identified by the presence of carbohydrate binding domains appended to uncharacterized domains with probable redox functions. Here, X-ray crystal structures of several domains from these proteins are presented together with initial efforts to characterize their functions. The analysis suggests that the target proteins are unlikely to function as LPMO electron donors, raising new questions as to the potential redox functions that these large extracellular multi-haem-containing c-type cytochromes may perform in these bacteria. Structural dissection of two redox proteins from the shipworm symbiont Teredinibacter turnerae.,Rajagopal BS, Yates N, Smith J, Paradisi A, Tetard-Jones C, Willats WGT, Marcus S, Knox JP, Firdaus-Raih M, Henrissat B, Davies GJ, Walton PH, Parkin A, Hemsworth GR IUCrJ. 2024 Mar 1;11(Pt 2):260-274. doi: 10.1107/S2052252524001386. PMID:38446458 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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