8qqi

E.coli DNA gyrase in complex with 217 bp substrate DNA and LEI-800

spinqualitylabelsall models 8qqi, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8qqi is a 6 chain structure with sequence from Escherichia coli and Escherichia phage Mu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.9Å Ligands: LRL, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A3K0QBM9_ECOLX A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897]

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