Structural highlights
8qws is a 2 chain structure with sequence from Streptomyces melanosporofaciens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.6Å |
| Ligands: | ACT, AHD, CL, EDO, MG, MPD, PG0 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
COTB2_STRMJ Catalyzes the cyclization of the linear isoprenoid intermediate geranylgeranyl diphosphate to tricycclic cyclooctat-9-en-7-ol in the cyclooctatin biosynthesis pathway. Cyclooctatin is a potent inhibitor of lysophospholipase.[1] [2]
References
- ↑ Kim SY, Zhao P, Igarashi M, Sawa R, Tomita T, Nishiyama M, Kuzuyama T. Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases. Chem Biol. 2009 Jul 31;16(7):736-43. doi: 10.1016/j.chembiol.2009.06.007. PMID:19635410 doi:https://dx.doi.org/10.1016/j.chembiol.2009.06.007
- ↑ Janke R, Gorner C, Hirte M, Bruck T, Loll B. The first structure of a bacterial diterpene cyclase: CotB2. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1528-37. doi:, 10.1107/S1399004714005513. Epub 2014 May 23. PMID:24914964 doi:https://dx.doi.org/10.1107/S1399004714005513
