8r4u

Structure of salt-inducible kinase 3 with inhibitors

spinqualitylabelsall models 8r4u, resolution 2.42Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8r4u is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.416Å Ligands: SO4, TPO, XW3 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease SIK3_HUMAN The disease is caused by variants affecting the gene represented in this entry. Function SIK3_HUMAN Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis (PubMed:30232230). Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus (By similarity).[UniProtKB:Q6P4S6]

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