Structural highlights
Disease
ZP2_HUMAN Female infertility due to zona pellucida defect. The disease is caused by variants affecting the gene represented in this entry.
Function
ZP2_HUMAN Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy (PubMed:29895852). The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor (PubMed:29895852).[1]
References
- ↑ Dai C, Hu L, Gong F, Tan Y, Cai S, Zhang S, Dai J, Lu C, Chen J, Chen Y, Lu G, Du J, Lin G. ZP2 pathogenic variants cause in vitro fertilization failure and female infertility. Genet Med. 2019 Feb;21(2):431-440. PMID:29895852 doi:10.1038/s41436-018-0064-y
