8rs4

Flavin-dependent tryptophan 6-halogenase Thal in complex with tryptoline

spinqualitylabelsall models 8rs4, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8rs4 is a 2 chain structure with sequence from Streptomyces albogriseolus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.2Å Ligands: GOL, NA, PO4, WYH Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TRP6H_STRAO Involved in the biosynthesis of thienodolin, a plant growth-regulating compound (PubMed:24692213). Catalyzes the chlorination of tryptophan (Trp) at C6 position to yield 6-chloro-tryptophan (PubMed:24692213, PubMed:33465708). It is also able to use bromide ions to generate monobrominated Trp (PubMed:33465708, PubMed:36259362). In vitro, accepts a wide range of amides and peptides carrying either L- or D-Trp at the N-terminus (PubMed:36259362).

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