8skw

MicroED structure of d(CGCGCG)2 Z-DNA

spinqualitylabelsall models 8skw, resolution 1.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8skw is a 2 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron crystallography, Resolution 1.1Å Ligands: SPM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Microcrystal electron diffraction (MicroED) is a powerful tool for determining high-resolution structures of microcrystals from a diverse array of biomolecular, chemical, and material samples. In this study, we apply MicroED to DNA crystals, which have not been previously analyzed using this technique. We utilized the d(CGCGCG)(2) DNA duplex as a model sample and employed cryo-FIB milling to create thin lamella for diffraction data collection. The MicroED data collection and subsequent processing resulted in a 1.10 A resolution structure of the d(CGCGCG)(2) DNA, demonstrating the successful application of cryo-FIB milling and MicroED to the investigation of nucleic acid crystals. Structure determination of a DNA crystal by MicroED.,Haymaker A, Bardin AA, Gonen T, Martynowycz MW, Nannenga BL Structure. 2023 Jul 24:S0969-2126(23)00248-4. doi: 10.1016/j.str.2023.07.005. PMID:37541248 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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