8sm6

Aerobic, Diiron(III)-metalated SfbO

spinqualitylabelsall models 8sm6, resolution 1.39Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8sm6 is a 4 chain structure with sequence from Litorilinea aerophila. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.39Å Ligands: FE, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A540VG95_9CHLR Publication Abstract from PubMed Dinuclear monooxygenases mediate challenging C-H bond oxidation reactions throughout nature. Many of these enzymes are presumed to exclusively utilize diiron cofactors. Herein we report the bioinformatic discovery of an orphan dinuclear monooxygenase that preferentially utilizes a heterobimetallic manganese-iron (Mn/Fe) cofactor to mediate an O(2)-dependent C-H bond hydroxylation reaction. Unlike the structurally similar Mn/Fe-dependent monooxygenase AibH2, the diiron form of this enzyme (SfbO) exhibits a nascent enzymatic activity. This behavior raises the possibility that many other dinuclear monooxygenases may be endowed with the capacity to harness cofactors with a variable metal content. Bioinformatic Discovery of a Cambialistic Monooxygenase.,Liu C, Powell MM, Rao G, Britt RD, Rittle J J Am Chem Soc. 2024 Jan 24;146(3):1783-1788. doi: 10.1021/jacs.3c12131. Epub 2024 , Jan 10. PMID:38198693 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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