8snm

Structure of mature human ADAM17/iRhom2 sheddase complex in complex with ADAM17 prodomain

spinqualitylabelsall models 8snm, resolution 3.84Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8snm is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.84Å Ligands: CA, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease RHDF2_HUMAN Palmoplantar keratoderma-esophageal carcinoma syndrome. The disease is caused by variants affecting the gene represented in this entry. Function RHDF2_HUMAN Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.[UniProtKB:Q80WQ6]

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