8swa

Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with SAM and PPNP

spinqualitylabelsall models 8swa, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8swa is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.999Å Ligands: K, MG, PPK, SAM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease METK1_HUMAN Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD) [MIM:250850; also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. Function METK1_HUMAN Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

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