8sxm | pdb_00008sxm

NMR structure of the ZNF750 zinc finger domain, Z*

spinqualitylabelsall models 8sxm Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8sxm is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Ligands: ACE, NH2, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease ZN750_HUMAN Seborrhea-like dermatitis with psoriasiform elements. The disease is caused by variants affecting the gene represented in this entry. Function ZN750_HUMAN Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression.

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