8sz5

[2T5] Self-assembling DNA motif with 5 base pairs between junctions and P32 symmetry

spinqualitylabelsall models 8sz5, resolution 2.89Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8sz5 is a 4 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.89Å Ligands: MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Tertiary chirality describes the handedness of supramolecular assemblies and relies not only on the primary and secondary structures of the building blocks but also on topological driving forces that have been sparsely characterized. Helical biopolymers, especially DNA, have been extensively investigated as they possess intrinsic chirality that determines the optical, mechanical, and physical properties of the ensuing material. Here, we employ the DNA tensegrity triangle as a model system to locate the tipping points in chirality inversion at the tertiary level by X-ray diffraction. We engineer tensegrity triangle crystals with incremental rotational steps between immobile junctions from 3 to 28 base pairs (bp). We construct a mathematical model that accurately predicts and explains the molecular configurations in both this work and previous studies. Our design framework is extendable to other supramolecular assemblies of helical biopolymers and can be used in the design of chiral nanomaterials, optically active molecules, and mesoporous frameworks, all of which are of interest to physical, biological, and chemical nanoscience. Engineering tertiary chirality in helical biopolymers.,Janowski J, Pham VAB, Vecchioni S, Woloszyn K, Lu B, Zou Y, Erkalo B, Perren L, Rueb J, Madnick J, Mao C, Saito M, Ohayon YP, Jonoska N, Sha R Proc Natl Acad Sci U S A. 2024 May 7;121(19):e2321992121. doi: , 10.1073/pnas.2321992121. Epub 2024 Apr 29. PMID:38684000 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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