8tj8

CRYSTAL STRUCTURE OF THE A/Moscow/10/1999(H3N2) INFLUENZA VIRUS HEMAGGLUTININ WITH HUMAN RECEPTOR ANALOG 6'-SLNLN

spinqualitylabelsall models 8tj8, resolution 2.56Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8tj8 is a 2 chain structure with sequence from Influenza A virus (A/Moscow/10/1999(H3N2)). Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.56Å Ligands: BMA, GAL, MAN, NAG, SIA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Hemagglutinins (HAs) from human influenza viruses descend from avian progenitors that bind alpha2-3-linked sialosides and must adapt to glycans with alpha2-6-linked sialic acids on human airway cells to transmit within the human population. Since their introduction during the 1968 pandemic, H3N2 viruses have evolved over the past five decades to preferentially recognize human alpha2-6-sialoside receptors that are elongated through addition of poly-LacNAc. We show that more recent H3N2 viruses now make increasingly complex interactions with elongated receptors while continuously selecting for strains maintaining this phenotype. This change in receptor engagement is accompanied by an extension of the traditional receptor-binding site to include residues in key antigenic sites on the surface of HA trimers. These results help explain the propensity for selection of antigenic variants, leading to vaccine mismatching, when H3N2 viruses are propagated in chicken eggs or cells that do not contain such receptors. Evolution of human H3N2 influenza virus receptor specificity has substantially expanded the receptor-binding domain site.,Thompson AJ, Wu NC, Canales A, Kikuchi C, Zhu X, de Toro BF, Canada FJ, Worth C, Wang S, McBride R, Peng W, Nycholat CM, Jimenez-Barbero J, Wilson IA, Paulson JC Cell Host Microbe. 2024 Feb 14;32(2):261-275.e4. doi: 10.1016/j.chom.2024.01.003. , Epub 2024 Feb 1. PMID:38307019 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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