8tl8

Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant in complex with bile acid

spinqualitylabelsall models 8tl8, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8tl8 is a 2 chain structure with sequence from Orthoreovirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.2Å Ligands: GCH Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SIGNS_REOVD Protein that binds to ssRNA and participates with protein mu-NS in forming the matrix of viral factories, which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place (PubMed:11152519). Plays a role in the inhibition of the integrated stress response (ISR) to escape from host cell translational shutoff (PubMed:28794026). Participates in the disruption of stress granules (SG) through its association with host G3BP1 and mu-NS (PubMed:28794026).

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