Structural highlights
8ugo is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.45Å |
| Ligands: | 2PE, 5AD, MET, PEG, PG4, PGE, PO4, YVI |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Disease
LIAS_HUMAN Lipoic acid synthetase deficiency. The disease is caused by variants affecting the gene represented in this entry.
Function
LIAS_HUMAN Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.[HAMAP-Rule:MF_03123]
