8v5s

VZV glycoprotein E C-terminal domain (cleaved) in complex with human Fab 5A2

spinqualitylabelsall models 8v5s, resolution 3.53Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8v5s is a 6 chain structure with sequence from Homo sapiens and Human alphaherpesvirus 3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.53Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A1B1JEP3_HHV3 In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.[ARBA:ARBA00025134]

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