8vhx

Cryo-EM of neck of bacteriophage Chi

spinqualitylabelsall models 8vhx, resolution 2.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8vhx is a 8 chain structure with sequence from Chivirus chi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.9Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function M9NTK8_9CAUD Publication Abstract from PubMed The flagellotropic bacteriophage chi (Chi) infects bacteria via the flagellar filament. Despite years of study, its structural architecture remains partly characterized. Through cryo-EM, we unveil chi's nearly complete structure, encompassing capsid, neck, tail, and tail tip. While the capsid and tail resemble phage YSD1, the neck and tail tip reveal new proteins and their arrangement. The neck shows a unique conformation of the tail tube protein, forming a socket-like structure for attachment to the neck. The tail tip comprises four proteins, including distal tail protein (DTP), two baseplate hub proteins (BH1P and BH2P), and tail tip assembly protein (TAP) exhibiting minimal organization compared to other siphophages. Deviating from the consensus in other siphophages, DTP in chi forms a trimeric assembly, reducing tail symmetry from 6-fold to 3-fold at the tip. These findings illuminate the previously unexplored structural organization of chi's neck and tail tip. Cryo-EM structure of flagellotropic bacteriophage Chi.,Sonani RR, Esteves NC, Scharf BE, Egelman EH Structure. 2024 Jul 11;32(7):856-865.e3. doi: 10.1016/j.str.2024.03.011. Epub , 2024 Apr 12. PMID:38614087 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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