8vkh

Structure of gelsolin domains G1-G3 bound to the barbed end of F-actin

spinqualitylabelsall models 8vkh, resolution 3.63Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8vkh is a 8 chain structure with sequence from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.63Å Ligands: ADP, ATP, CA, HIC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ACTS_RABIT Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Publication Abstract from PubMed Gelsolin is the prototypical member of a family of Ca (2+) -dependent F-actin severing and capping proteins. A structure of Ca (2+) -bound full-length gelsolin at the barbed end shows domains G1G6 and the inter-domain linkers wrapping around F-actin. Another structure shows domains G1G3, a fragment produced during apoptosis, on both sides of F-actin. Conformational changes that trigger severing occur on one side of F-actin with G1G6 and on both sides with G1G3. Gelsolin remains bound after severing, blocking subunit exchange. Mechanism of Actin Filament Severing and Capping by Gelsolin.,Barrie KR, Rebowski G, Dominguez R bioRxiv [Preprint]. 2024 Sep 23:2024.09.10.612341. doi: , 10.1101/2024.09.10.612341. PMID:39345426 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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