Structural highlights
Function
VGPCR_HHV8P Receptor that signals constitutively via several signaling pathways including PI3K/AKT as well as mitogen- and stress-activated/MAP kinases. Promotes host cell proliferation and survival, modulates cell migration, stimulates angiogenesis, and recruits inflammatory cells, both in expressing cells and in neighboring cells. Maintains chronic activation of NF-kappa-B via interaction with host CADM1 (PubMed:29698475).[1] [2] [3]
References
- ↑ Cannon M, Philpott NJ, Cesarman E. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor has broad signaling effects in primary effusion lymphoma cells. J Virol. 2003 Jan;77(1):57-67. PMID:12477810 doi:10.1128/jvi.77.1.57-67.2003
- ↑ Cannon ML, Cesarman E. The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells. Oncogene. 2004 Jan 15;23(2):514-23. PMID:14724579 doi:10.1038/sj.onc.1207021
- ↑ Hunte R, Alonso P, Thomas R, Bazile CA, Ramos JC, van der Weyden L, Dominguez-Bendala J, Khan WN, Shembade N. CADM1 is essential for KSHV-encoded vGPCR-and vFLIP-mediated chronic NF-κB activation. PLoS Pathog. 2018 Apr 26;14(4):e1006968. PMID:29698475 doi:10.1371/journal.ppat.1006968
