8x4n

Crystal structure of the PI3P-binding domain of Legionella SetA in complex with inositol 1,3-bisphosphate

spinqualitylabelsall models 8x4n, resolution 2.46Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8x4n is a 2 chain structure with sequence from Legionella pneumophila. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.46Å Ligands: GOL, ITP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SETA_LEGPH Secreted effector that interferes with vesicular trafficking of host cells. Possesses glucohydrolase and mono-O-glucosyltransferase activity by using UDP-glucose as a sugar donor substrate. Is able to glucosylate histones H4 and H3.1 in vitro, but it is unlikely that histones are the natural substrates for SetA. May glycosylate a component of the host cell vesicle trafficking machinery during L.pneumophila infection. Binds with high specificity to phosphatidylinositol 3-phosphate (PtdIns(3)P), (with a dissociation constant value of 809 nM), which guides SetA to the cytosolic leaflet of the early phagosome of the host cell.

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