8x62 | pdb_00008x62

crystal structure of human Mcl-1 kinase domain in complex with RM1

spinqualitylabelsall models 8x62, resolution 2.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8x62 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.8033946Å Ligands: YO0 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MCL1_HUMAN Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

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