8xwn

Structure of CXCR2 bound to CXCL8 (Ligand-receptor focused map)

spinqualitylabelsall models 8xwn, resolution 3.29Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8xwn is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.29Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease CXCR2_HUMAN Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency. Function CXCR2_HUMAN Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

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